1899 Hoffenheim vs Lyon Prediction

I'm backing Lyon to avoid defeat here. Hoffenheim sit 30th in the Europa League table with zero points after two losses, while Lyon sit 8th with six points from two wins. The gap in European form is stark, and I see Lyon's away record as the decisive edge on 22 October 2026 at 22:00.

Hoffenheim lost 2-3 to Besiktas at home in their last Europa League match and have won just one of their last nine games across all competitions. I've noted they scored only twice in that Besiktas defeat, and in 9 of their last 10 matches they've managed no more than two goals. That's a ceiling I can't ignore when facing a disciplined opponent.

Lyon, by contrast, have not lost in 9 of their last 10 away matches in this competition. I'm impressed by their consistency: in those same nine outings they've registered at least four shots on target and scored in 9 of 10 recent matches across all tournaments. Their defence is tighter still—in their last 10 games they've conceded no more than two goals in any single match. Even if Hoffenheim find the net, I don't see them overturning Lyon's control.

Form and H2H

I need to flag that Hoffenheim have lost six of nine matches this season but did beat Borussia Mönchengladbach 2-1 in the Bundesliga to snap a four-game losing run. That win came before this trip, so there's a sliver of momentum, but it's fragile against Lyon's pedigree away from home.

The head-to-head record favours Hoffenheim on paper—they've drawn all three previous meetings and never lost to Lyon. I'm not swayed by that. Home advantage is real, but it doesn't override the current form gap. Lyon have won their last two matches at home, beating Crystal Palace 3-2 in Europa League and Nice 2-1 in Ligue 1.

I'm also watching Lyon's injury list. Lois Openda, Nicolas Tagliafico, and Mohamadi Ouedraogo are out, but their squad depth has held firm in away matches. Hoffenheim are missing Nathan De Kat, Albian Hajdari, and Patrick Wimmer, which limits their attacking options further.

Best bet

I'm taking Lyon to not lose at 3.37 on the 1xBet double chance X2. That's my main play. The price reflects Hoffenheim's home status, but I believe it undervalues Lyon's away consistency and Hoffenheim's current fragility in Europe.

I'll also consider Both Teams Score at 1.44 on 1xBet. Hoffenheim have scored in 8 of their last 10 matches across all tournaments, and Lyon score regularly on the road. The odds are tight, which tells me the market sees this as likely, but I prefer the safety of the draw or away win at 3.37.

Odds to watch

The 1xBet 1X2 line sits at 2.07 for Hoffenheim, 3.98 for the draw, and 3.37 for Lyon. I think 3.37 on Lyon is the sharpest price here, but if I want to hedge I'll look at Over 2.5 at 1.46 versus Under 2.5 at 2.47. The market leans toward goals, and I agree—Lyon's attacking threat combined with Hoffenheim's need to push forward should produce at least three goals.

The Asian Handicap -0.25 for Hoffenheim at 1.81 is tempting if you want home backing, but I prefer the safety of X2. If you're chasing bigger odds, the draw alone at 3.98 is worth a look given the three previous meetings all ended level. For me, 3.37 on Lyon not to lose captures the value without overextending.